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Mouse Anti-human CD4/FITC Conjugated antibody (bsm-30093M-FITC)
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说 明 书: 25T  50T  100T
25T/220.00元
50T/360.00元
100T/580.00元
大包装/询价

产品编号 bsm-30093M-FITC
英文名称1 Mouse Anti-human CD4/FITC Conjugated antibody
中文名称 FITC标记的小鼠抗人CD4单克隆抗体
别    名 LHR; BA-1; CD 44; CD44 antigen; CD44 molecule; CD44_HUMAN; CDw44; Cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; ECMR-III; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HSA; HUTCH-I; HUTCH1; Hyaluronate receptor; MDU2; MDU3; MIC4; MUTCH1; PGP-1; PGP1; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; CD44 antigen isoform 1 precursor.  
规格价格 25T/220元 购买    50T/360元 购买    100T/580元 购买    大包装/询价
说 明 书 25T  50T  100T
研究领域 肿瘤  细胞生物  免疫学  细胞表面分子  t-淋巴细胞  
抗体来源 Mouse
克隆类型 Monoclonal
克 隆 号 HIT4a
交叉反应
产品应用 Flow-Cyt=10ul/Test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
免 疫 原 KLH conjugated synthetic peptide derived from human CD4
亚    型 Mouse IgG2b
纯化方法 affinity purified by Protein G
储 存 液 0.01M PBS, 0.5%BSA, 0.03% Proclin300
保存条件 Store at 2-8℃. Protect from light. Avoid freezing.
产品介绍 background:
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010].

Function:
Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.

Subunit:
Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.

Post-translational modifications:
Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.

Similarity:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Database links:


Entrez Gene: 920 Human

SwissProt: P01730 Human





Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

此抗体可识别55KDⅠ型单链穿膜糖蛋白。 CD4分子是存在于大多数辅助/诱导T细胞表面的59kDa的糖蛋白。正常淋巴组织中CD4的表达数量多于CD8,此抗体主要用于标记辅助/诱导T细胞,与CD8单抗联合使用对外周血淋巴细胞分型。 CD4抗原是HLA-II类分子和人类免疫缺陷病毒(HIV)-爱滋病的受体,在35-50%外周血淋巴细胞-辅助和诱导T细胞(Th/Ti)和70-80%人胸腺细胞上表达,在人的单核细胞表面也有低密度的表达。 CD4抗原有膜结合型和可溶性两种形式。Th/Ti可辅助Ig产生和T细胞毒T细胞的作用。
产品图片
scatter diagram showing peripheral blood lymphocytes stained with bsm-30093M-FITC. The cells were incubated with the antibody (bsm-30093M-FITC, 5 µl/Test) for 30 min at 22°C. Acquisition of >10,000 events was performed.
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