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Rabbit Anti-IL22BP /Cy7 Conjugated antibody (bs-23535R-Cy7)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-23535R-Cy7
英文名称1 Rabbit Anti-IL22BP /Cy7 Conjugated antibody
中文名称 Cy7标记的白介素22受体结合蛋白抗体
别    名 IL22RA2; Interleukin-22 receptor subunit alpha-2; IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; Interleukin-22-binding protein; IL-22BP; IL22BP; Cytokine receptor family 2 member 10; CRF2-10; Cytokine receptor class-II member 10; Cytokine receptor family type 2, soluble 1; CRF2-S1; ZcytoR16; I22R2_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 免疫学  细胞表面分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Mouse, Rat, )
产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse IL22BP
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
There are two isoforms of IL22 RA2 produce by alternative splicing. Isoform 1 may play a role in establishing and maintaining successful pregnancy. Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). It may play an important role as an IL22 antagonist in the regulation of inflammatory responses.

Function:
Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Isoform 1 may play a role in establishing and maintaining successful pregnancy.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach.

Similarity:
Belongs to the type II cytokine receptor family.
Contains 3 fibronectin type-III domains.

Database links:

Entrez Gene: 116379 Human

Omim: 606648 Human

SwissProt: Q969J5 Human

Unigene: 126891 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

白介素22结合蛋白是一种新型的Ⅱ类细胞因子受体家族成员,它能直接结合IL-22,作为IL-22的拮抗剂,发挥着多种生物学功能。
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