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Rabbit Anti-IRS-2/RBITC Conjugated antibody (bs-20748R-RBITC)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-20748R-RBITC
英文名称1 Rabbit Anti-IRS-2/RBITC Conjugated antibody
中文名称 罗丹明(RBITC)标记的胰岛素受体底物-2抗体
别    名 Insulin Receptor Substrate 2; IRS 2; IRS-2; IRS2; IRS2_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  细胞凋亡  细胞膜受体  糖尿病  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Rat,  (predicted: Mouse, Horse, )
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 146kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IRS-2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]

Function:
May mediate the control of various cellular processes by insulin.

Subunit:
Interacts with PHIP.

Subcellular Location:
Cytoplasm, cytosol.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Contains 1 IRS-type PTB domain.
Contains 1 PH domain.

Database links:

Entrez Gene: 8660 Human

Entrez Gene: 384783 Mouse

Entrez Gene: 29376 Rat

Omim: 600797 Human

SwissProt: Q9Y4H2 Human

SwissProt: P81122 Mouse

Unigene: 442344 Human

Unigene: 407207 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

IRS-2是肝胰岛素信号转导核心介子,IRS-2基因的缺失或IRS-2信号网络上一些关键信号分子的异常改变,都将导致肝胰岛素信号转导能力减弱,出现肝胰岛素抵抗.
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