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Rabbit Anti-TMEPAI/Cy7 Conjugated antibody (bs-12668R-Cy7)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-12668R-Cy7
英文名称 Anti-TMEPAI/Cy7
中文名称 Cy7标记的跨膜前列腺雄激素诱导蛋白1抗体
别    名 PMEPA_HUMAN; PMEPA1; Prostate transmembrane protein, androgen induced 1; Solid tumor associated 1 protein; Solid tumor-associated 1 protein; STAG1; Transmembrane prostate androgen induced protein; Transmembrane prostate androgen-induced protein; Transmembrane, prostate androgen induced RNA.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  生长因子和激素  跨膜蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse,  (predicted: Rat, Chicken, Sheep, )
产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 32kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TMEPAI
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Function:
Involved in down-regulation of the androgen receptor (AR). Enhances ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Highest expression in prostate. Also expressed in ovary.

Similarity:
Belongs to the PMEPA1 family.

Database links:

Entrez Gene: 56937 Human

Omim: 606564 Human

SwissProt: Q969W9 Human

Unigene: 517155 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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