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Rabbit Anti-Opticin/AF488 Conjugated antibody (bs-19647R-AF488)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-19647R-AF488
英文名称 Anti-Opticin/AF488
中文名称 AF488标记的Opticin蛋白抗体
别    名 Oculoglycan; OPT; OPT_HUMAN; OPTC; Opticin.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig, Cat, )
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Opticin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). [provided by RefSeq, Jul 2008]

Function:
Binds collagen fibrils.

Subcellular Location:
Secreted > extracellular space > extracellular matrix.Entrez Gene: 26254 Human Entrez Gene: 269120 Mouse Entrez Gene: 304802 Rat Omim: 605127 Human SwissProt: Q9UBM4 Human SwissProt: Q920A0 Mouse Unigene: 632468 Human Unigene: 59985 Mouse

Tissue Specificity:
Retina, iris, ligament, skin and fetal liver.

Post-translational modifications:
O-glycosylated.

Similarity:
Belongs to the small leucine-rich proteoglycan (SLRP) family.
SLRP class III subfamily.
Contains 6 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain.

Database links:

Entrez Gene: 26254 Human

Entrez Gene: 269120 Mouse

Entrez Gene: 304802 Rat

Omim: 605127 Human

SwissProt: Q9UBM4 Human

SwissProt: Q920A0 Mouse

Unigene: 632468 Human

Unigene: 59985 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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