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Rabbit Anti-GPR106/Gold Conjugated antibody (bs-20083R-Gold)
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说 明 书: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包装/询价
产品编号 bs-20083R-Gold
英文名称1 Rabbit Anti-GPR106/Gold Conjugated antibody
中文名称 胶体金标记的G蛋白偶联受体106抗体
别    名 G protein coupled receptor 106; G-protein coupled receptor 106; G protein coupled receptor affecting testicular descent; GPR106; GPR-106; GREAT; INSL3R; Leucine rich repeat containing G protein coupled receptor 8; LGR8; Relaxin/insulin-like family peptide receptor 2; Relaxin family peptide receptor 2; Relaxin receptor 2; Relaxin receptor-2; RXFP 2; RXFP-2; RXFP2; RXFPR2; RXFP2_HUMAN; GPCR LGR8.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul(10nm  15nm  35nm
研究领域 细胞生物  神经生物学  信号转导  细胞膜受体  内分泌病  G蛋白偶联受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应
产品应用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 86kDa
性    状 Lyophilized or Liquid
浓    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GPR106
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存条件 Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles.
产品介绍 background:
This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].

Function:
The activity of this relaxin receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP and may also be a receptor for Leydig insulin-like peptide. LGR8 has been reported in blood, bone marrow, brain, kidney, muscle, testis, thyroid, and uterus.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow.

DISEASE:
Defects in RXFP2 are a cause of cryptorchidism (CRYPTO) [MIM:219050]; also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer.

Similarity:
Belongs to the G-protein coupled receptor 1 family.
Contains 1 LDL-receptor class A domain.
Contains 10 LRR (leucine-rich) repeats.

Database links:

Entrez Gene: 122042 Human

Entrez Gene: 140498 Mouse

Entrez Gene: 363866 Rat

Omim: 606655 Human

SwissProt: Q8WXD0 Human

SwissProt: Q91ZZ5 Mouse

Unigene: 680763 Human

Unigene: 444643 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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