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Rabbit Anti-DRG1/Biotin Conjugated antibody (bs-20290R-Bio)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-20290R-Bio
英文名称1 Rabbit Anti-DRG1/Biotin Conjugated antibody
中文名称 生物素标记的GTP发育调控结合蛋白1抗体
别    名 Developmentally regulated GTP binding protein 1; Developmentally-regulated GTP-binding protein 1; DRG 1; DRG-1; DRG1; DRG1_HUMAN; NEDD 3; NEDD-3; NEDD3; Neural precursor cell expressed developmentally down regulated protein 3; Neural precursor cell expressed developmentally down-regulated protein 3.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  发育生物学  信号转导  细胞周期蛋白  转录调节因子  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应
产品应用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 41kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DRG1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
May play a role in cell proliferation, differentiation and death.High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes.

Function:
Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest.

Subunit:
Interacts (via its C-terminal) with TAL1. Interacts with ZC3H15; the interaction forms a polysomal DRG1-DFRP1/ZC3H15 complex which provides protein stability to DRG1 possibly by blocking poly-ubiquitination. Interacts with STK16; the interaction phosphorylates STK16

Subcellular Location:
Cytoplasm. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes.

Tissue Specificity:
High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes.

Post-translational modifications:
Sumoylated by UBE2I in response to MEKK1-mediated stimuli.

Similarity:
Belongs to the GTP1/OBG family.
Contains 1 G (guanine nucleotide-binding) domain.

Database links:

Entrez Gene: 4733 Human

Entrez Gene: 13494 Mouse

Entrez Gene: 305470 Rat

Omim: 603952 Human

SwissProt: Q9Y295 Human

SwissProt: P32233 Mouse

SwissProt: Q5I0F0 Rat

Unigene: 115242 Human

Unigene: 3250 Mouse

Unigene: 102143 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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