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Rabbit Anti-METTL1/RBITC Conjugated antibody (bs-18814R-RBITC)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-18814R-RBITC
英文名称 Rabbit Anti-METTL1/RBITC Conjugated antibody
中文名称 罗丹明(RBITC)标记的甲基化样蛋白1抗体
别    名 C12orf1; D1075 like gene product; FLJ95748; Methyltransferase like 1; Methyltransferase like protein 1; Methyltransferase-like protein 1; Mettl1; TRM8; TRMB_HUMAN; TRMT8; tRNA (guanine N(7) ) methyltransferase; tRNA (guanine(46)-N(7))-methyltransferase; tRNA (guanine-N(7)-)-methyltransferase; tRNA(m7G46) methyltransferase; tRNA(m7G46)-methyltransferase; YDL201w.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse,  (predicted: Rat, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human METTL1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]

Function:
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

Subcellular Location:
Nucleus.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylation at Ser-27 inactivates its catalytic activity but does not affect the interaction with WDR4.

Similarity:
Belongs to the methyltransferase superfamily. TrmB family.

Database links:

Entrez Gene: 511197 Cow

Entrez Gene: 4234 Human

Entrez Gene: 17299 Mouse

GenBank: BC000550 Human

Omim: 604466 Human

SwissProt: Q2YDF1 Cow

SwissProt: Q9UBP6 Human

SwissProt: Q9Z120 Mouse

Unigene: 42957 Human

Unigene: 251593 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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