| 产品编号 | bs-17509R-BF555 |
| 英文名称 | Rabbit Anti-SKOR2/BF555 Conjugated antibody |
| 中文名称 | BF555标记的SKOR2蛋白抗体 |
| 别 名 | CORL2; Functional smad suppressing element 18; Functional Smad-suppressing element on chromosome 18; Fussel-18; FUSSEL18; Ladybird homeobox corepressor 1-like protein; LBX1 corepressor 1-like protein; SKI family transcriptional corepressor 2; SKOR2; SKOR2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 信号转导 生长因子和激素 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, (predicted: Human, Dog, Cow, Sheep, ) |
| 产品应用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 104kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SKOR2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 |
background: The sloan kettering virus (Ski) family of nuclear oncoproteins act as transcriptional regulators of TGF-β by interacting directly with SMAD proteins. Fussel-18 (functional Smad-suppressing element on chromosome 18), also known as SKOR2 (Ski family transcriptional corepressor 2), LBX1 corepressor 1-like protein, ladybird homeobox corepressor 1-like protein or CORL2, is a 1,001 amino acid protein that belongs to the Ski family. Localizing to nucleus as well as cytoplasm, Fussel-18 is expressed in cerebellum, spinal cord and testis. Fussel-18 acts as an antagonist to TGF-β in the nervous system, possibly by functioning as a transcriptional repressor of SMAD2 and SMAD3. Existing as two alternatively spliced isoforms, the gene encoding Fussel-18 maps to human chromosome 18q21.1 and mouse chromosome 18 E3. Function: Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system. Subcellular Location: Nucleus. Cytoplasm. Tissue Specificity: Expressed in cerebellum, spinal cord and testis. Isoform 2 is present in cerebellum (at protein level). Similarity: Belongs to the SKI family. Database links: Entrez Gene: 652991 Human SwissProt: Q2VWA4 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
