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Rabbit Anti-KRT83/Gold Conjugated antibody (bs-16857R-Gold)
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说 明 书: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包装/询价
产品编号 bs-16857R-Gold
英文名称 Rabbit Anti-KRT83/Gold Conjugated antibody
中文名称 胶体金标记的角蛋白KRT83抗体
别    名 KRTHB3; Hair keratin K2.10; Hard keratin, type II, 3; HB 3; HB3; hHb3; K2.10; K83; Keratin 83; Keratin; Keratin, hair, basic, 3; Keratin-83; Krt83; KRT83_HUMAN; KRTHB3; type II cuticular Hb3; Type II hair keratin Hb3; Type-II keratin Kb23.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul(10nm  15nm  35nm
研究领域 细胞生物  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Cow, Sheep, )
产品应用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 54kDa
性    状 Lyophilized or Liquid
浓    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KRT83
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存条件 Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles.
产品介绍 background:
This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B. [provided by RefSeq, May 2012]

Function:
Heterotetramer of two type I and two type II keratins.

Tissue Specificity:
Synthesis begins in the cortex 10-15 cell layers above the apex of the dermal papilla and ends abruptly in the middle of the cortex.

DISEASE:
Defects in KRT83 are a cause of monilethrix (MLTRX) [MIM:158000]. Monilethrix is an autosomal dominant hair disorder characterized clinically by alopecia and follicular papules. Affected hairs have uniform elliptical nodes of normal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp is involved, but in severe forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected.

Similarity:
Belongs to the intermediate filament family.

Database links:

Entrez Gene: 3889 Human

Entrez Gene: 406219 Mouse

Entrez Gene: 300246 Rat

Omim: 602765 Human

SwissProt: P78385 Human

SwissProt: Q6IMF0 Mouse

Unigene: 720768 Human

Unigene: 347934 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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