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Rabbit Anti-KPNA4/PE-Cy7 Conjugated antibody (bs-16804R-PE-Cy7)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-16804R-PE-Cy7
英文名称 Rabbit Anti-KPNA4/PE-Cy7 Conjugated antibody
中文名称 PE-Cy7标记的KPNA4蛋白抗体
别    名 FLJ31113; IMA4_HUMAN; Importin alpha 3; Importin alpha 4 subunit; Importin alpha Q1; Importin subunit alpha 3; Importin subunit alpha-4; IPO A3; IPOA 3; IPOA3; Karyopherin alpha 4 (importin alpha 3); Karyopherin alpha 4; Karyopherin alpha 4 importin alpha 3; Karyopherin alpha 4 subunit; Karyopherin subunit alpha 4; Karyopherin subunit alpha-4; KPNA 4; Kpna4; MGC12217; MGC26703; OTTHUMP00000213880; QIP 1; Qip1; Qip1 protein; SRP 3; SRP3.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  染色质和核信号  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,  (predicted: Human, Rat, Chicken, Cow, Horse, )
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 57kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KPNA4
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]

Function:
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a nonclassical NLS.

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes.

Similarity:
Belongs to the importin alpha family.
Contains 10 ARM repeats.
Contains 1 IBB domain.

Database links:

Entrez Gene: 3840 Human

Entrez Gene: 535090 Cow

Entrez Gene: 478680 Dog

Entrez Gene: 100171548 Orangutan

Entrez Gene: 100349259 Rabbit

Entrez Gene: 702486 Rhesus monkey

Omim: 602970 Human

SwissProt: O00629 Human

Unigene: 288193 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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