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Rabbit Anti-GTPBP4/PE Conjugated antibody (bs-16368R-PE)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-16368R-PE
英文名称1 Rabbit Anti-GTPBP4/PE Conjugated antibody
中文名称 PE标记的G蛋白结合蛋白4/慢性肾功能衰竭蛋白抗体
别    名 Chronic renal failure gene protein; CRFG; G protein binding protein CRFG; GTP binding protein 4; GTP-binding protein NGB; Gtpbp4; NGB; NOG1; NOG1_HUMAN; Nucleolar GTP binding protein 1; Nucleolar GTP-binding protein 1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  肿瘤细胞生物标志物  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 74kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GTPBP4
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]

Function:
Involved in the biogenesis of the 60S ribosomal subunit.

Subcellular Location:
Nucleus; nucleolus.

Similarity:
Belongs to the GTP1/OBG family. NOG subfamily.

Database links:

Entrez Gene: 23560 Human

Entrez Gene: 69237 Mouse

Entrez Gene: 114300 Rat

SwissProt: Q9BZE4 Human

SwissProt: Q99ME9 Mouse

SwissProt: Q99P77 Rat

Unigene: 215766 Human

Unigene: 41800 Mouse

Unigene: 96111 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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