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Rabbit Anti-ERLEC1/APC Conjugated antibody (bs-14625R-APC)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-14625R-APC
英文名称1 Rabbit Anti-ERLEC1/APC Conjugated antibody
中文名称 APC标记的内质网凝集素1抗体
别    名 C2orf30; CL24936; CL2508; endoplasmic reticulum lectin 1; ER lectin; erlectin 1; RP23 20N14.5; ERLEC_HUMAN; XTP3 B; XTP3 transactivated gene B protein; XTP3 transactivated protein B; XTP3B; XTP3TPB.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  转运蛋白  泛素  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ERLEC1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. [provided by RefSeq, Aug 2011]

Function:
ERLEC1 is a probable lectin that binds selectively to improperly folded lumenal proteins. ERLEC1 may function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.

Subunit:
May form a complex with OS9, HSPA5, SYVN1, and SEL1L with which it interacts directly. Interacts (via PRKCSH 2 domain) with KREMEN2 (when glycosylated). Interacts with HSPA5.

Subcellular Location:
Endoplasmic reticulum lumen.

Post-translational modifications:
Isoform 1 and isoform 2 are N-glycosylated.

Similarity:
Contains 2 PRKCSH domains.

Database links:

Entrez Gene: 27248 Human

Omim: 611229 Human

SwissProt: Q96DZ1 Human

Unigene: 438336 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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