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Rabbit Anti-CUG-BP1/2/PE-Cy5 Conjugated antibody (bs-14562R-PE-Cy5)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-14562R-PE-Cy5
英文名称1 Rabbit Anti-CUG-BP1/2/PE-Cy5 Conjugated antibody
中文名称 PE-Cy5标记的胞苷尿苷鸟苷结合蛋白1/2,神经母细胞瘤细胞凋亡相关RNA结合蛋白抗体
别    名 CUG-BP1; CUG-BP12; Elav-type RNA-binding protein ETR3; Bruno-like protein 3; BRUNOL3; Cardiac elav type RNA binding protein; CELF-2; celf2; CELF2_HUMAN; CUG BP2; CUG triplet repeat RNA-binding protein 2; CUG-BP- and ETR-3-like factor 2; CUG-BP2; CUGBP Elav like family member 2; CUGBP Elav-like family member 2; CUGBP2; dJ323N1.1; elav type RNA binding protein; ELAV-type RNA-binding protein 3; ETR 3; ETR-3; HGNC:2550; hNAPOR; NAPOR 2; NAPOR; Neuroblastoma apoptosis-related RNA-binding protein; Neuroplastoma apoptosis related RNA binding protein 3; RNA binding protein BRUNOL3; RNA-binding protein BRUNOL-3.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  结合蛋白  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Pig, Cow, Rabbit, Xenopus laevis)
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 54kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CUG-BP1 and CUG-BP2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Function:
RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats.

Subcellular Location:
Nucleus. Cytoplasm. Accumulates in the cytoplasm after ionizing radiation (By similarity). Colocalizes with APOBEC1 and A1CF. RNA-binding activity is detected in both nuclear and cytoplasmic compartments.

Tissue Specificity:
Expressed in frontal cortex. Isoform 1 is expressed in brain and lung. Isoform 2 is expressed in heart, brain, placenta, lung, liver, kidney, skeletal muscle and pancreas. Isoform 4 is expressed in heart, lung, skeletal muscle, kidney and pancreas.

Similarity:
Belongs to the CELF/BRUNOL family.
Contains 3 RRM (RNA recognition motif) domains.

Database links:

Entrez Gene: 10659 Human

Entrez Gene: 14007 Mouse

Entrez Gene: 100335150 Xenopus laevis

Entrez Gene: 379280 Xenopus laevis

Entrez Gene: 373117 Zebrafish

Omim: 602538 Human

SwissProt: Q7T2T1 Chicken

SwissProt: O95319 Human

SwissProt: Q9Z0H4 Mouse

SwissProt: Q7ZXE2 Xenopus laevis

SwissProt: Q6P0B1 Zebrafish

Unigene: 309288 Human

Unigene: 398543 Mouse

Unigene: 1068 Xenopus laevis

Unigene: 85486 Xenopus laevis

Unigene: 77531 Zebrafish



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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