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Rabbit Anti-Connexin 31.1/PE Conjugated antibody (bs-13734R-PE)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-13734R-PE
英文名称1 Rabbit Anti-Connexin 31.1/PE Conjugated antibody
中文名称 PE标记的间隙连接蛋白31.1/GJB5抗体
别    名 Connexin 31.1; Connexin-31.1; Connexin31.1; Cx31.1; CXB5_HUMAN; Gap junction beta 5 protein; Gap junction beta-5 protein; Gap junction protein beta 5 31.1kDa; Gap junction protein beta 5; GJB 5; GJB5.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  细胞粘附分子  跨膜蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Connexin 31.1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
产品介绍 background:
The connexin family of proteins form hexameric complexes, called connexons, that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane ?helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino acid substitutions in the most highly conserved domains; the transmembrane and extracellular regions. Connexin 31.1, Cx31.1 or Gap junction beta-5 protein, is a 271 amino acid protein that is predominantly expressed in skin with lower expression in testis. Expression of connexin 31.1 is required for normal placental development in mice. Down-regulation of the connexin 31.1 gene correlates with head and neck squamous cell carcinomas (HNSCC) and therefore it may be a potential therapeutic target.

Function:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Subcellular Location:
Cell membrane. Cell junction > gap junction.

Similarity:
Belongs to the connexin family. Beta-type (group I) subfamily.

Database links:

Entrez Gene: 2709 Human

Omim: 604493 Human

SwissProt: O95377 Human

Unigene: 198249 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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