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Rabbit Anti-AHNAK/Biotin Conjugated antibody (bs-13624R-Bio)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-13624R-Bio
英文名称 Anti-AHNAK/Biotin
中文名称 生物素标记的神经细胞分化相关蛋白AHNAK抗体
别    名 AHNAK; AHNAK nucleoprotein (desmoyokin); AHNAKRS; AHNK_HUMAN; Desmoyokin; Fragments; MGC5395; Neuroblast differentiation associated protein AHNAK; Neuroblast differentiation-associated protein AHNAK; PM227.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 心血管  神经生物学  细胞分化  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, )
产品应用 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 629kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human AHNAK
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
AHNAK is a 5,890 amino acid protein encoded by the human gene AHNAK. The intronless AHNAK gene is located on human chromosome 11q12 and has three main structural regions: the 251 amino acid N-terminus, a large central region of 4390 amino acids with multiple repeated units of about 128 amino acids in length, and the 1002 amino acid C-terminus. The central region seems to have antiparallel beta-strands connected by intervening loops. Several putative regulatory elements are clustered within the C-terminal region, including nuclear export localization signals, a leucine zipper, and potential phosphorylation sites for Akt1 and PKC. AHNAK is believed to be an important signalling molecule involved in a wide range of physiological activities and may be required for neuronal cell differentiation.. AHNAK also appears to influence b-adrenergic regulation of cardiac L-type Ca2+ channel function.

Function:
May be required for neuronal cell differentiation.

Subunit:
Interacts with DYSF; the interaction is direct and Ca(2+)-independent.

Subcellular Location:
Nucleus.

Similarity:
Contains 1 PDZ (DHR) domain.

Database links:

Entrez Gene: 79026 Human

Entrez Gene: 66395 Mouse

Entrez Gene: 191572 Rat

Entrez Gene: 718802 Rhesus monkey

Omim: 103390 Human

SwissProt: Q09666 Human

Unigene: 502756 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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