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Rabbit Anti-TRPC1/AF647 Conjugated antibody (bs-10404R-AF647)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-10404R-AF647
英文名称 Anti-TRPC1/AF647
中文名称 AF647标记的瞬时受体电位通道1抗体
别    名 TRPC1_HUMAN; Short transient receptor potential channel 1; TrpC1; Transient receptor protein 1; TRP-1; TRP 1; TRP 1 protein; TRP1; TRP1 protein; . HTRP 1; HTRP1; MGC133334; MGC133335; Mtrp1; Transient receptor potential cation channel subfamily C member 1; Transient receptor potential channel 1; Trp related protein 1; TRPC1; Trpc1 transient receptor potential cation channel subfamily C member 1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
产品应用 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 87kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRPC1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

Function:
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

Subunit:
Interacts with TRPC4AP. Homotetramer and heterotetramer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5. Interacts with ITPR3. Interacts with MX1 and RNF24. Interacts with FKBP4.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Seems to be ubiquitous.

Similarity:
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
Contains 4 ANK repeats.

Database links:

Entrez Gene: 7220 Human

Entrez Gene: 22063 Mouse

Entrez Gene: 89821 Rat

Omim: 602343 Human

SwissProt: P48995 Human

SwissProt: Q61056 Mouse

SwissProt: Q9QX01 Rat

Unigene: 250687 Human

Unigene: 149633 Mouse

Unigene: 88592 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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