| 产品编号 | bs-10144R-Gold |
| 英文名称1 | Rabbit Anti-CD35/Gold Conjugated antibody |
| 中文名称 | 胶体金标记的Ⅰ型补体受体抗体（C3b/C4b受体抗体） |
| 别 名 | C3 binding protein; C3b/C4b receptor; C3BR; C4BR; CD 35; CD35; CD35 antigen; complement component (3b/4b) receptor 1 (Knops blood group); complement component (3b/4b) receptor 1 including Knops blood group system; Complement component receptor 1; Complement receptor 1; Complement receptor type 1; CR 1; CR1; CR1_HUMAN; KN; Knops blood group antigen. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul（10nm 15nm 35nm） |
| 研究领域 | 免疫学 细胞膜受体 淋巴细胞 t-淋巴细胞 b-淋巴细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | (predicted: Human, ) |
| 产品应用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 274kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CR1/CD35 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存条件 | Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 产品介绍 |
background: This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. Function: Mediates cellular binding of particles and immune complexes that have activated complement. Subunit: Monomer. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. Similarity : Belongs to the receptors of complement activation (RCA) family. Contains 30 Sushi (CCP/SCR) domains. Database links: Entrez Gene: 1378 Human Omim: 120620 Human SwissProt: P17927 Human Unigene: 334019 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD35广泛分布于红细胞、粒细胞、单核细胞、肥大细胞、滤泡树突状细胞、肾小球足突细胞、B细胞及部分CD4+T细胞表面.CD35抗原又称为CR1或者C3b/C4b R，是一种分子量160-250kDa的C3b/C4b补体结合跨膜蛋白，主要用于滤泡树突状细胞标记和滤泡树突状细胞瘤的诊断。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
