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Rabbit Anti-DBPA/Cy7 Conjugated antibody (bs-12985R-Cy7)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-12985R-Cy7
英文名称1 Rabbit Anti-DBPA/Cy7 Conjugated antibody
中文名称 Cy7标记的冷休克蛋白DBPA抗体
别    名 Cold shock domain containing protein A; Cold shock domain-containing protein A; csdA; CSDA1; DBPA; DNA binding protein A; DNA-binding protein A; Single strand DNA binding protein NF GMB; Single-strand DNA-binding protein NF-GMB; ZO 1 associated nucleic acid binding protein; ZO1 associated nucleic acid binding protein; ZONAB; YBOX3_HUMAN; Y-box-binding protein 3.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  信号转导  细胞周期蛋白  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Rabbit, Sheep, )
产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 40kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DBPA/CSDA1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
CSDA is a 372 amino acid nuclear and cytoplasmic protein that is highly expressed in skeletal muscle and heart. Containing one CSD (cold-shock) domain, CSDA is thought to bind to GM-CSF promoter, full length mRNA and to short RNA sequences containing a specific consensus site. CSDA is suggested to have a role in translation repression and is found in a mRNP complex with MSY2. MSY2 belongs to the Y-box family of multifunctional proteins that regulate both transcription and translation. CSDA participates in promoting cell proliferation and expression of cyclin D1 and proliferating cell nuclear antigen (PCNA). CSDA is regarded to be an important component of the mechanisms that sense epithelial density and in regulating the switch between proliferation and differentiation through complex transcriptional networks.

Function:
Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression.

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Highly expressed in skeletal muscle and heart.

Similarity:
Contains 1 CSD (cold-shock) domain.

Database links:

Entrez Gene: 8531 Human

Entrez Gene: 56449 Mouse

Entrez Gene: 83807 Rat

Omim: 603437 Human

SwissProt: P16989 Human

SwissProt: Q61478 Mouse

SwissProt: Q68G78 Mouse

SwissProt: Q8BPG0 Mouse

SwissProt: Q9JKB3 Mouse

SwissProt: Q3KRC7 Rat

SwissProt: Q62764 Rat

Unigene: 221889 Human

Unigene: 299604 Mouse

Unigene: 458000 Mouse

Unigene: 3306 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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