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Rabbit Anti-SLC7A9/AF350 Conjugated antibody (bs-10085R-AF350)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-10085R-AF350
英文名称 Anti-SLC7A9/AF350
中文名称 AF350标记的离子转运相关蛋白SLC7A9抗体
别    名 B(0+) type amino acid transporter 1; BAT1; CSNU3; Glycoprotein associated amino acid transporter b0+AT1; Solute carrier family 7 (cationic amino acid transporter y+ system) member 9; BAT1_HUMAN; B(0,+)-type amino acid transporter 1; B(0,+)AT; Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 免疫学  通道蛋白  交换蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat,  (predicted: Human, Dog, Pig, Rabbit, )
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 53kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SLC7A9
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
SLC7A9 belongs to the amino acid-polyamine-organocation (APC) superfamily. It is a disulfide linked heterodimer with the amino acid transport protein SLC3A1. SLC7A9 is involved in the high affinity, sodium independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high affinity reabsorption of cystine in the kidney tubule. Defects in SLC7A9 are a cause of non type I cystinuria (CSNU). CSNU arises from impaired transport of cystine and dibasic amino acids through the epithelial cells of the renal tubule and gastrointestinal tract. Three types of cystinuria have been described: type I (fully recessive or silent); type II (high excretor); type III (moderate excretor). Defects in SLC7A9 are associated with type II and type III cystinuria. They also might account for some non classic type I cystinuria cases.

Function:
Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney tubule.

Subunit:
Disulfide-linked heterodimer with the amino acid transport protein SLC3A1.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Kidney, small intestine, liver and placenta.

Similarity:
Belongs to the amino acid-polyamine-organocation (APC) superfamily.

Database links:

Entrez Gene: 11136 Human

Entrez Gene: 30962 Mouse

Entrez Gene: 116726 Rat

Omim: 604144 Human

SwissProt: P82251 Human

SwissProt: Q3UQE3 Mouse

SwissProt: Q9QXA6 Mouse

SwissProt: P82252 Rat

SwissProt: Q4KM04 Rat

Unigene: 408567 Human

Unigene: 45874 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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