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Rabbit Anti-CRTAC1/Biotin Conjugated antibody (bs-12948R-Bio)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-12948R-Bio
英文名称 Anti-CRTAC1/Biotin
中文名称 生物素标记的软骨酸性蛋白1抗体
别    名 68 kDa chondrocyte expressed protein; 68 kDa chondrocyte-expressed protein; Acidic secreted protein in cartilage; ASPIC; ASPIC1; Cartilage acidic protein 1; Cartilage acidic protein 1 precursor; CEP 68; CEP-68; CEP68; CRAC1_HUMAN; CRTAC1; Protein CRTAC1-B; W307.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  干细胞  生长因子和激素  细胞分化  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Cow, Sheep, )
产品应用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 68kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CRTAC1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
CRTAC1 is a 661 amino acid secreted protein. CRTAC1 is O-glycosylated and contains one EGF-like domain and four FG-GAP repeats. Up-regulated in mesenchymal stem cells undergoing chondrogenic differentiation and also by growth factor BMP-4, CRTAC1 is found in the interterritorial matrix of articular deep zone cartilage. CRTAC1 is expressed as three isoforms produced by alternative splicing events. All isoforms are expressed in bone, cartilage and lung, while isoforms 1 and 2 are expressed in the brain. The gene that encodes CRTAC1 maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome.

Subcellular Location:
Secreted; extracellular space; extracellular matrix.

Tissue Specificity:
Expressed in the interterritorial matrix of articular deep zone cartilage (at protein level). Isoform 1 and isoform 2 are expressed in brain. Isoform 1 is detected in lung and chondrocytes. Detected in cartilage, bone, cultured chondrocytes and lung, and at low levels in heart. Not detected in osteoblasts.

Post-translational modifications:
O-glycosylated.

Similarity:
Contains 1 EGF-like domain.
Contains 4 FG-GAP repeats.

Database links:
UniProtKB/Swiss-Prot: Q9NQ79.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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