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Rabbit Anti-SCP3/AP Conjugated antibody (bs-10660R-AP)
~~~促销,代码KT202502A~~~
~~~促销,代码KT202502B~~~
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-10660R-AP
英文名称 Rabbit Anti-SCP3/AP Conjugated antibody
中文名称 碱性磷酸酶(AP)标记的胆碱磷酸转移酶1抗体
别    名 SCP3; choline phosphotransferase 1; chpt1; COR 1; COR1; MGC71888; RNASCP3; SCP 3; SCP-3; SPGF4; Sycp 3; Sycp3; SYCP3_HUMAN; Synaptonemal complex protein 3.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  染色质和核信号  细胞周期蛋白  细胞分化  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,  (predicted: Human, Rat, )
产品应用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SYCP3
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]

Function:
Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2.

Subunit:
Interacts with SYCP2.

Subcellular Location:
Nucleus. Chromosome. Note=In tripartite segments of synaptonemal complexes, irrespective of whether these are synapsed or unsynapsed.

Tissue Specificity:
Testis-specific.

Post-translational modifications:
Phosphorylated.

DISEASE:
Spermatogenic failure 4 (SPGF4) [MIM:270960]: An infertility disorder characterized by azoospermia, a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the XLR/SYCP3 family.

Database links:

Entrez Gene: 50511 Human

Entrez Gene: 20962 Mouse

Entrez Gene: 25561 Rat

Omim: 604759 Human

SwissProt: Q8IZU3 Human

SwissProt: P70281 Mouse

SwissProt: Q63520 Rat

Unigene: 506504 Human

Unigene: 297977 Mouse

Unigene: 34889 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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