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Rabbit Anti-Glypican 6/FITC Conjugated antibody (bs-2177R-FITC)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-2177R-FITC
英文名称 Anti-Glypican 6/FITC
中文名称 FITC标记的磷脂酰基醇蛋白聚糖-6抗体
别    名 GPC 6; Glypican6; Glypican-6; Glypican 6 [Precursor]; Glypican proteoglycan 6; GPC 6; GPC6; MGC126288; Secreted glypican 6.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  信号转导  生长因子和激素  细胞表面分子  细胞骨架  锌指蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Horse, Rabbit, )
产品应用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 56kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Glypican 6
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Glypican 6 is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti proteases. The glypicans comprise a family of glycosylphosphatidylinositol anchored heparan sulfate proteoglycans. The glypicans have been implicated in the control of cell growth and division.

Function:
Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted glypican-6: Secreted, extracellular space.

Tissue Specificity:
Widely expressed. High expression in fetal kidney and lung and lower expressions in fetal liver and brain. In adult tissues, very abundant in ovary, high levels also observed in liver, kidney, small intestine and colon. Not detected in peripheral blood leukocytes.

DISEASE:
Defects in GPC6 are a cause of omodysplasia type 1 (OMOD1) [MIM:258315]. OMOD1 is a rare autosomal recessive skeletal dysplasia characterized by severe congenital micromelia with shortening and distal tapering of the humeri and femora to give a club-like appearance. Typical facial features include a prominent forehead, frontal bossing, short nose with a depressed broad bridge, short columella, anteverted nostrils, long philtrum, and small chin.

Similarity:
Belongs to the glypican family.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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