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Rabbit Anti-IL12/Cy7 Conjugated antibody (bs-0767R-Cy7)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-0767R-Cy7
英文名称 Rabbit Anti-IL12/Cy7 Conjugated antibody
中文名称 Cy7标记的白介素12抗体
别    名 IL12; IL-12; CLMF p35; CLMF1; CTL maturation factor (TcMF); Cytotoxic lymphocyte maturation factor 1; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL 12 subunit p35; IL12A; Interleukin 12 alpha chain; Interleukin 12 p35; Interleukin 12A; Natural killer cell stimulatory factor 1; CLMF; CLMF p35; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL-12 subunit p35; IL-12A; IL12 subunit p35; IL12A; IL12A_HUMAN; Interleukin 12 p35; Interleukin 12A; Interleukin-12 subunit alpha; NFSK; NK cell stimulatory factor chain 1; NKSF1. NK cell stimulatory factor chain 1; NKSF1; p35; IL12A_MOUSE.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat, 
产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse IL-12
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
IL-12 protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.

Function:
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.

Subunit:
Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.

Subcellular Location:
Secreted.

Similarity:
Belongs to the IL-6 superfamily.

Database links:

Entrez Gene: 3592 Human

Entrez Gene: 16159 Mouse

Entrez Gene: 84405 Rat

Omim: 161560 Human

SwissProt: P29459 Human

SwissProt: P43431 Mouse

SwissProt: Q9R103 Rat

Unigene: 673 Human

Unigene: 103783 Mouse

Unigene: 207199 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

IL-12是新近发现的细胞因子,具有多种生物学活性,尤其是在抗肿瘤免疫和抗病毒免疫中有重要的作用。
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