| 产品编号 | bs-4121R-APC |
| 英文名称 | Anti-Exendin 4/APC |
| 中文名称 | APC标记的GLP1类似蛋白Exendin4抗体 |
| 别 名 | Exendin 4; Exendin4; Exendin-4; EXE4_HELSU . |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 神经生物学 糖尿病 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | |
| 产品应用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 4.3kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from Gila monster lizard Exendin 4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 |
background: Exendin 4 is a 39 amino acid peptide found in venom from the Gila monster Helicoderma suspectum. It is a member of the glucagon secretin family of peptide hormones and neuropeptides. Exendin 4 is a potent agonist of the GLP1 receptor and hence a potent stimulator of insulin secretion. Function: Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle. Subcellular Location: Secreted. Tissue Specificity: Expressed by the venom gland. Similarity: Belongs to the glucagon family. Database links: UniProtKB/Swiss-Prot: P26349.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Exendin-4是从希拉毒蜥唾液中分离的一种多肽激素,由39个氨基酸残基组成,与胰高血糖素样肽1(GLP-1)有53%的同源性。Exendin-4具有高度的组织特异性,仅在希拉毒蜥的唾液腺中表达, 具有促进葡萄糖依赖性的胰岛素分泌、促进β细胞增殖、减慢胃排空、抑制食物摄取和减轻体重等作用。 肠促胰岛素类似物（exendin-4，Ex-4）是从美洲一种毒蜥的唾液中分泌的胰升糖素样肽-1（glucagon-like peptide-1，GLP-1）类似物，它具有促进胰腺胰岛素的分泌、增加胰岛素敏感性及改善胰岛细胞功能的作用，且不被二肽基肽酶Ⅳ（DPP-Ⅳ）分解，血浆半衰期较长，因而在人类，对糖尿病治疗应用来说是稳定、长效的有治疗前景的药物。 钝尾毒蜥 (Gila monster) |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
