产品编号 | bs-5450R-APC |
英文名称1 | Rabbit Anti-phospho-ICAM1 (Tyr512)/APC Conjugated antibody |
中文名称 | APC标记的磷酸化细胞间粘附分子1抗体 |
别 名 | BB2; CD54 antigen; ICAM1; ICAM 1; ICAM-1; Cell surface glycoprotein P3.58; Human rhinovirus receptor; ICAM 1; Intercellular adhesion molecule 1; Major group rhinovirus receptor; MALA2; MyD10; P3.58; Surface antigen of activated B cells; ICAM1_HUMAN. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
产品类型 | 磷酸化抗体 |
研究领域 | 肿瘤 细胞生物 信号转导 干细胞 细胞膜受体 细胞粘附分子 细胞表面分子 糖蛋白 细胞类型标志物 t-淋巴细胞 b-淋巴细胞 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, |
产品应用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 55kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human ICAM1 around the phosphorylation site of Tyr512 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 |
background: ICAM proteins are ligands for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2). Subcellular Located at Membrane; single-pass type I membrane protein. Tissue Specificified Expressed at low level on a subpopulation of lymphocytes, macrophages, and endothelial cells, but is strongly induced on these cells, and on fibroblasts and epithelial cells. [PTM] Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis (By similarity). It belongs to the immunoglobulin superfamily. ICAM family. Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus. Subunit: Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus. Subcellular Location: Membrane; Single-pass type I membrane protein. Post-translational modifications: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. Similarity: Belongs to the immunoglobulin superfamily. ICAM family. Contains 5 Ig-like C2-type (immunoglobulin-like) domains. Database links: Entrez Gene: 3383 Human Entrez Gene: 15894 Mouse Omim: 147840 Human Unigene: 643447 Human SwissProt: P05362 Human SwissProt: P13597 Mouse Unigene: 435508 Mouse Unigene: 12 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
1、抗体溶解方法 | |
2、抗体修复方式 | |
3、常用试剂的配制 | |
4、免疫组化操作步骤 | |
5、免疫组化问题解答 | |
6、Western Blotting 操作步骤 | |
7、Western Blotting 问题解答 | |
8、关于肽链的设计 | |
9、多肽的溶解与保存 | |
10、酶标抗体效价测定程序 | |