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Rabbit Anti-SRP68/BF647 Conjugated antibody (bs-2381R-BF647)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-2381R-BF647
英文名称 Rabbit Anti-SRP68/BF647 Conjugated antibody
中文名称 BF647标记的信号识别颗粒抗体
别    名 Signal recognition particle 68 kDa; Signal recognition particle subunit SRP68; Signal recognition particle 68 kDa protein; SRP 68; Srp68; SRP68_HUMAN.   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 免疫学  染色质和核信号  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,  (predicted: Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 71kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SRP68
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.

Function:
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.

Subunit:
Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

Subcellular Location:
Cytoplasm. Nucleus, nucleolus.

Similarity:
Belongs to the SRP68 family.

Database links:

Entrez Gene: 6730 Human

Entrez Gene: 217337 Mouse

Entrez Gene: 363707 Rat

Omim: 604858 Human

SwissProt: Q9UHB9 Human

SwissProt: Q8BMA6 Mouse

Unigene: 514495 Human

Unigene: 29655 Mouse

Unigene: 68 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

信号识别颗粒(Signalrecognitionparticle,SRP)是介导蛋白识别转运其中普遍存在的机制之一,细胞内蛋白质的定向转移是蛋白质质量数量控制体系的一个重要环节,SRP对参与这一过程的功能基因和蛋白,尤其是蛋白的靶向输送机制的研究对揭示细胞的分化、代谢和病变具有重大的理论意义.
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