扫码关注公众号           扫码咨询技术支持           扫码咨询技术服务
  
客服热线:400-901-9800  客服QQ:4009019800  技术答疑  技术支持  质量反馈  关于我们  联系我们
产品中心-北京博奥森生物技术有限公司
首页 > 产品中心 > 标记一抗 > 产品信息
Rabbit Anti-SFRP4/BF350 Conjugated antibody (bs-1331R-BF350)
订购热线:400-901-9800
订购邮箱:sales@bioss.com.cn
订购QQ:  400-901-9800
技术支持:techsupport@bioss.com.cn
说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-1331R-BF350
英文名称 Rabbit Anti-SFRP4/BF350 Conjugated antibody
中文名称 BF350标记的子宫内膜抗体
别    名 sFRP-4; Secreted frizzled-related protein 4; Frizzled protein, human endometrium; FrpHE; SFRP4; SFRP4_MOUSE; SFRP4_HUMAN; FRPHE.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 免疫学  干细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Rabbit, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 38kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human sFRP-4 C-terminus
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. [SUBCELLULAR LOCATION] Secreted. Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Belongs to the secreted frizzled-related protein (sFRP) family.

Function:
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (By similarity).

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed the ovary. Localized to granulosa cells of periovulatory follicles and corpora lutea. Weakly expressed in adult tissues including kidney, brain and lung.

Similarity:
Belongs to the secreted frizzled-related protein (sFRP) family.
Contains 1 FZ (frizzled) domain.
Contains 1 NTR domain.

Database links:

Entrez Gene: 6424 Human

Entrez Gene: 20379 Mouse

Entrez Gene: 89803 Rat

Omim: 606570 Human

SwissProt: Q6FHJ7 Human

SwissProt: Q9Z1N6 Mouse

SwissProt: Q9JLS4 Rat

Unigene: 658169 Human

Unigene: 42095 Mouse

Unigene: 10788 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

抗子宫内膜抗体属于自身抗体,在正常育龄妇女中也可以检测到,但在不孕症人群中,特别是患有子宫内膜异位症的妇女中更多见。
正常机体具有自身免疫调节功能,产生极弱的自身抗体,帮助清除体内衰老变性的自身成分,但由于某种原因导致免疫系统对自身组织产生过度免疫应答,则会发生过强的一系列免疫反应,致使所侵及的组织免疫活性细胞增多,免疫复合物沉积,而导致功能改变。当这种抗子宫内膜抗体由于反复刺激而大量产生达到一定的含量时,可与自身的子宫内膜组织发生抗原抗体结合反应,并激活免疫系统引起损伤性效应,造成子宫内膜组织细胞生化代谢及生理功能的损害,干扰和妨碍精卵结合,受精卵的着床和胚囊的发育而导致不孕或流产。
版权所有 2004-2026 www.bioss.com.cn 北京博奥森生物技术有限公司
通过国际质量管理体系ISO 9001:2015 GB/T 19001-2016    证书编号: 00124Q34771R2M/1100
通过国际医疗器械-质量管理体系ISO 13485:2016 GB/T 42061-2022    证书编号: CQC24QY10047R0M/1100
京ICP备05066980号-1         京公网安备110107000727号