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Rabbit Anti-T Beta 10/PE Conjugated antibody (bs-1088R-PE)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-1088R-PE
英文名称 Rabbit Anti-T Beta 10/PE Conjugated antibody
中文名称 PE标记的胸腺素β10抗体
别    名 MIG 12; MIG12; Migration inducing gene 12; Migration inducing protein 12; Ptmb10; TB 10; TB10; Thyb 10; Thyb10; Thymosin beta-10; Thymosin beta 10; TMSB10; TYB10_HUMAN  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  免疫学  生长因子和激素  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 4.9kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human T Beta 10
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The beta thymosins are a family of related peptides, initially isolated from calf thymus but known to be present in a wide variety of mammalian and other vertebrate cells and tissues. Thymosin beta 4 was the first member of the family to be characterized. Although TMSB4 was initially proposed to be a thymic hormone acting at early stages of T cell maturation, the high concentration of the protein and its mRNA in a number of other tissues and cells, as well as the lack of an identifiable secretory signal sequence, suggested that it had a general function in many cell types. Thymosin beta 10 is closely related in sequence to TMSB4 and is also an actin sequestering protein.

Function:
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.

Subcellular Location:
Cytoplasm, cytoskeleton.

Similarity:
Belongs to the thymosin beta family.

Database links:

Entrez Gene: 9168 Human

Entrez Gene: 100364435 Rat

Entrez Gene: 50665 Rat

Omim: 188399 Human

SwissProt: P63313 Human

SwissProt: Q596K9 Human

SwissProt: P63312 Rat

Unigene: 446574 Human

Unigene: 5983 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

胸腺素β10同其他胸腺素一样也是多肽类激素,具有增强细胞免疫功能和调节免疫平衡等作用,胸腺素可使由骨髓产生的干细胞转变为T淋巴细胞,因而可增强细胞免疫功能,对体液免疫的影响甚微。
近年来研究认为:该蛋白于肿瘤转移有关,胸腺素β10在肿瘤转移潜能的增高伴有肌动蛋白多聚体的丢失和微丝结构的解聚,微丝骨架的这种变化与Tβ10的表达增高具有相关性。
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