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Rabbit Anti-TSLP/Gold Conjugated antibody (bs-0449R-Gold)
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说 明 书: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包装/询价
产品编号 bs-0449R-Gold
英文名称1 Rabbit Anti-TSLP/Gold Conjugated antibody
中文名称 胶体金标记的胸腺基质淋巴细胞生成素-1抗体
别    名 Thymic stromal lymphopoietin isoform 1; Thymic stromal lymphopoietin; Thymic stromal lymphopoietin protein TSLP; TSLP protein; TSLP_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul(10nm  15nm  35nm
研究领域 细胞生物  免疫学  细胞因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, )
产品应用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 15kDa
性    状 Lyophilized or Liquid
浓    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TSP-1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存条件 Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles.
产品介绍 background:
Thymic stromal lymphopoietin (TSLP) is a novel cytokine that was found to promote the development of murine B cells in vitro. This protein, which is expressed in a number of tissues including heart, liver and prostate, prevented apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ-3. Anti-interleukin (IL)-7 receptor antibodies (Abs) neutralized this effect indicating that TSLP binds to at least part of the IL-7 receptor complex. TSLP induced phosphorylation of signal transducer and activator of transcription (STAT)-5.

Function:
Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.

Subunit:
Interacts with a receptor composed of CRLF2 and IL7R.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in a number of tissues including heart, liver and prostate.

Database links:

Entrez Gene: 85480 Human

Entrez Gene: 53603 Mouse

Entrez Gene: 688621 Rat

Omim: 607003 Human

SwissProt: Q969D9 Human

SwissProt: Q9JIE6 Mouse

Unigene: 389874 Human

Unigene: 143716 Mouse

Unigene: 201724 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

胸腺基质淋巴细胞生成素-1(胸腺基质细胞分泌的淋巴细胞生成素-1)
为一种新型促进生长的细胞因子——胸腺基质淋巴蛋白(TSLP)可以引发炎症反应, 这种炎症反应可以引起很多过敏性疾病和哮喘。
TSLP可能是过敏性疾病最重要的引发剂,已得到科学家的重视,如果证实了 TSLP是一种起始因子,抑制TSLP可以有效地治疗哮喘和其它过敏性疾病。
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