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Rabbit Anti-TPH/HRP Conjugated antibody (bs-1215R-HRP) ~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-1215R-HRP
英文名称 Anti-TPH/HRP
中文名称 辣根过氧化物酶标记的色氨酸羟化酶抗体
别    名 MGC119994; TPH 1; TPH; TPH1; TPRH; Tryptophan 5 hydroxylase 1; Tryptophan 5 monooxygenase 1; Tryptophan 5 monooxygenase; Tryptophan hydroxylase 1; Tryptophan 5-hydroxylase 1; TPH1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat,  (predicted: Chicken, Dog, Horse, Rabbit, )
产品应用 WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TPH
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009].

Subunit:
Homotetramer.

Tissue Specificity:
Isoform 2 seems to be less widely expressed than isoform 1.

Similarity:
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Contains 1 ACT domain.

Database links:

Entrez Gene: 7166 Human

Entrez Gene: 21990 Mouse

Entrez Gene: 24848 Rat

Omim: 191060 Human

SwissProt: P17752 Human

SwissProt: P17532 Mouse

SwissProt: P09810 Rat

Unigene: 591999 Human

Unigene: 248684 Mouse

Unigene: 94788 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

色氨酸在脑中首先由色氨酸羟化酶(tryoptophan hydroxylase)催化生成5羟色氨酸(5hydroxytryptophan),再经脱羧酶作用生成5羟色胺,色氨酸羟化酶(TPH)是5-HT生物合成的限速酶,因此,色氨酸羟化酶的缺少可导致5-羟色胺的含量下降。色氨酸羟化酶主要在肝脏内代谢。
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