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Rabbit Anti-IGSF11/BF350 Conjugated antibody (bs-9201R-BF350)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-9201R-BF350
英文名称1 Rabbit Anti-IGSF11/BF350 Conjugated antibody
中文名称 BF350标记的大脑和睾丸特异性免疫球蛋白超家族成员11抗体
别    名 brain and testis specific immunoglobin superfamily protein; BTIGSF; CXADR like 1; CXADRL1; Igsf13; immunoglobulin superfamily member 11; Immunoglobulin superfamily member 11 precursor; MGC35227; V set and immunoglobulin domain containing 3; V set and immunoglobulin domain containing protein 3; VSIG3; IGS11_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  细胞周期蛋白  细胞膜受体  细胞表面分子  细胞分化  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,  (predicted: Human, Rat, Cow, Horse, Rabbit, Sheep, )
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IGSF11
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
IGSF11 is also known as BTIGSF (brain and testis-specific immunoglobulin superfamily protein) or VSIG3 (V-set and immunoglobulin domain-containing protein 3) and is a 431 amino acid protein that is expressed as three isoforms. IGSF11 is highly expressed in testis and ovary and is also expressed in brain, kidney and skeletal muscle, localized to the cellular membrane as a single-pass membrane protein. IGSF11 is an immunoglobulin with V-type and C2-type domains that function in molecular recognition. When IGSF11 is in the trans position, it plays an important role in cell-cell adhesion via both homophilic and heterophilic interactions with other molecules. These cell–cell interactions are also thought to be important for neuronal cell interactions, such as neuron–neuron or neuron–glia interactions, which are important for the development and function of the central nervous system. In addition, IGSF11 might also be involved interactions between Sertoli cells and spermatocytes, which are important associations during spermatogenesis. The IGSF11 gene is commonly upregulated in gastric cancer and IGSF11 is highly expressed in many types of human tumors, indicating that it may be useful as a target for immunotherapy.

Function:
Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth.

Subcellular Location:
Cell Membrane, Single-pass type I membrane protein.

Tissue Specificity:
bundantly expressed in testis and ovary and to a lower extent in brain, kidney and skeletal muscle.

Post-translational modifications:
N-glycosylated (By similarity).

Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Database links:

Entrez Gene: 152404 Human

Entrez Gene: 207683 Mouse

Entrez Gene: 303926 Rat

Omim: 608351 Human

SwissProt: Cow

SwissProt: Q5DX21 Human

SwissProt: P0C673 Mouse

SwissProt: Q5U2P2 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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