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Rabbit Anti-VGLL2/Cy7 Conjugated antibody (bs-9183R-Cy7)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-9183R-Cy7
英文名称 Rabbit Anti-VGLL2/Cy7 Conjugated antibody
中文名称 Cy7标记的转录辅助因子退变样蛋白2抗体
别    名 Protein VITO1; Transcription cofactor vestigial like 2; Transcription cofactor vestigial like protein 2; Transcription cofactor vestigial-like protein 2; Vestigial like 2; Vestigial like 2 (Drosophila); Vgl-2; VGL2; VGLL 2; Vgll2; VGLL2_HUMAN; VITO1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  信号转导  干细胞  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, )
产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human VGLL2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Vgl-2, also known as VITO-1, is a 317 amino acid protein that contains a domain through which it interacts with TEF-1, a protein that plays a role in controlling the expression of numerous genes. Specific to skeletal muscle, Vgl-2 is expressed highly in adult fast muscle and is expressed at lower levels in adult slow muscle and fetal skeletal muscle. During muscle differentiation, Vgl-2 mRNA levels increase and Vgl-2 translocates from the cytoplasm to the nucleus. Overexpression of Vgl-2 in MYOD-transfected 10T1/2 mouse embryonic fibroblasts increases expression of myosin heavy chain (MHC), which is a marker of terminal muscle differentiation. This evidence suggests that Vgl-2 is essential for muscle gene expression. There are two isoforms of Vgl-2 that are produced as a result of alternative splicing events.

Function:
May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles.

Subunit:
Interacts with TEFs. Binds to TEAD1/TEF1.

Subcellular Location:
Nucleus.

Tissue Specificity:
Skeletal muscle.

Similarity:
Belongs to the vestigial family.

Database links:

Entrez Gene: 245806 Human

Entrez Gene: 215031 Mouse

Omim: 609979 Human

SwissProt: Q8N8G2 Human

SwissProt: Q8BGW8 Mouse

Unigene: 99324 Human

Unigene: 87237 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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