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Rabbit Anti-Nociceptin/AP Conjugated antibody (bs-0075R-AP)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-0075R-AP
英文名称 Rabbit Anti-Nociceptin/AP Conjugated antibody
中文名称 碱性磷酸酶(AP)标记的孤菲肽/痛敏肽抗体
别    名 PNOC; N/OFQ; N23K; N23K/N27K; Nociceptin, included; Npnc1; OFQ; OFQ/N; Orphanin FQ; PPNOC; prepronociceptin; Propronociceptin; PNOC_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  心血管  神经生物学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, )
产品应用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 20kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Nociceptin (130-146aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Nociceptin (PNOC) is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. Expressed predominantly in the spinal cord and brain, being more abundant in the hypothalamus and striatum. Also found in small amounts in ovary. Belongs to the opioid neuropeptide precursor family.


Function:
Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development (By similarity).

Subcellular Location:
Secreted.

Tissue Specificity:
Predominantly in the brain and spinal cord.

Similarity:
Belongs to the opioid neuropeptide precursor family.

Database links:

Entrez Gene: 5368 Human

Entrez Gene: 18155 Mouse

Entrez Gene: 25516 Rat

Omim: 601459 Human

SwissProt: Q13519 Human

SwissProt: Q64387 Mouse

SwissProt: Q62923 Rat

Unigene: 88218 Human

Unigene: 16347 Mouse

Unigene: 486163 Mouse

Unigene: 87935 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

孤菲肽(Nociceptin又称为Orphanin FQ; PPNOC; ORL1)是新发现的一种神经肽,由17个氨基酸组成,又称痛敏肽。消化道肿瘤病人的血浆中OFQ含量明显高于对照组,尤以结肠癌、胃癌最为明显。
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