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Rabbit Anti-Neurocan/HRP Conjugated antibody (bs-1055R-HRP)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-1055R-HRP
英文名称1 Rabbit Anti-Neurocan/HRP Conjugated antibody
中文名称 辣根过氧化物酶标记的神经粘蛋白抗体
别    名 Chondroitin sulfate proteoglycan 3; Cspg3; NCAN; NEUR; Neurocan core protein; NCAN_HUMAN.   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 发育生物学  神经生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,  (predicted: Human, Rat, )
产品应用 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 140kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Neurocan
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Neurocan is the major soluble chondroitin sulfate proteoglycan in the brain. It is thought to play a functional role in axonal growth and guidance and in the establishment of specific neural pathways during embryonic brain development. Neurocan expression in the brain is developmentally regulated. Early on the major form of neurocan consists of a 245kD core protein with approximately two chondroitin sulfate glycosoaminoglycan chains of 22kD each. Later neurocan comprises a 180kD core protein Both forms of neurocan contain only chondroitin 4-sulfate glycosoaminoglycan chains. By virtue of their high expression at sites of neural damage and trauma, chondroitin sulfate proteoglycans, including neurocan, are thought to inhibit successful nerve regeneration. Alternative names: Chondroitin sulfate proteoglycan 3; Cspg3; NCAN; NEUR; Neurocan core protein.

Function:
May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

Subcellular Location:
Secreted.

Tissue Specificity:
Brain.

Similarity:
Belongs to the aggrecan/versican proteoglycan family.
Contains 1 C-type lectin domain.
Contains 2 EGF-like domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Contains 2 Link domains.
Contains 1 Sushi (CCP/SCR) domain.

Database links:

Entrez Gene: 1463 Human

Entrez Gene: 58982 Rat

Omim: 600826 Human

SwissProt: O14594 Human

SwissProt: P55067 Rat

Unigene: 169047 Human

Unigene: 10177 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神经生物学相关蛋白(Neurobiology)
神经粘蛋白(Neurocan)是由神经元分泌的特异性蛋白质,广泛分布于神经系统,可与神经元细胞膜上特异性受体神经粘附分子和神经元胶质细胞黏附分子结合,调节细胞连接,影响轴突生长.而在中枢神经系统损伤后,Neurocan的表达增加,并抑制轴突生长.Neurocan在中枢神经系统的形成和损伤后的修复都扮演着重要的角色.
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