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Rabbit Anti-RAB40A/Gold Conjugated antibody (bs-8366R-Gold)
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说 明 书: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包装/询价
产品编号 bs-8366R-Gold
英文名称 Rabbit Anti-RAB40A/Gold Conjugated antibody
中文名称 胶体金标记的RAS癌基因家族蛋白RAB40A抗体
别    名 Protein Rar 2; RAB40A, member RAS oncogene family; Rar 2; RAR2A; Ras related protein Rab 40A; SOCS box containing protein RAR2A; RB40A_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul(10nm  15nm  35nm
研究领域 肿瘤  细胞生物  免疫学  信号转导  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Chicken, Cow, Rabbit, Sheep, )
产品应用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
性    状 Lyophilized or Liquid
浓    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RAB40A
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存条件 Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles.
产品介绍 background:
The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies all of which are thought to play an important role in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum (ER) to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rab proteins are also an integral part of endocytic pathways. Rab 40A, Rab 40B and Rab 40C each contain one SOCS box domain and are members of the Rab subfamily of GTPases. Localized to the cytoplasmic side of the cell membrane, Rab 40A, Rab 40B and Rab 40C are thought to function as substrate-recognition components of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex that functions to mediate the degradation of target proteins.

Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Subcellular Location:
Cell membrane; Lipid anchor; Cytoplasmic side (Potential).

Similarity:
Belongs to the small GTPase superfamily. Rab family.
Contains 1 SOCS box domain.

Database links:

Entrez Gene: 142684 Human

SwissProt: Q8WXH6 Human

Unigene: 706904 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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