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Rabbit Anti-BRSK1/FITC Conjugated antibody (bs-7905R-FITC)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-7905R-FITC
英文名称 Rabbit Anti-BRSK1/FITC Conjugated antibody
中文名称 FITC标记的丝氨酸/苏氨酸蛋白激酶SAD-B抗体
别    名 BR serine/threonine kinase 1; BR serine/threonine protein kinase 1; BR serine/threonine-protein kinase 1; Brain-specific serine/threonine-protein kinase 1; BRSK 1; Brsk1; BRSK1_HUMAN; Protein kinase SAD1A; SAD 1; SAD1; SAD1 kinase; SAD1A; SADB; SadB kinase short isoform; Serine/threonine kinase SAD B; Serine/threonine-protein kinase SAD-B; Synapses of Amphids Defective homolog; FLJ43009; KIAA1811.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  细胞周期蛋白  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Rat,  (predicted: Human, Mouse, Pig, Cow, Horse, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 86kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BRSK1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Required for the polarization of forebrain neurons which endows axons and dendrites with distinct properties, possibly by locally regulating phosphorylation of microtubule-associated proteins (By similarity). May be involved in the regulation of G2/M arrest in response to UV- or methyl methane sulfonate (MMS)-induced, but not IR-induced, DNA damage. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo.
Tissue specificity: Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.

Subcellular Location:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome. Cell junction, synapse. Note=Localizes to synaptic vesicles in neurons. Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage.

Tissue Specificity:
Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.

Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Contains 1 protein kinase domain.
Contains 1 UBA domain.

Database links:

Entrez Gene: 84446 Human

Entrez Gene: 381979 Mouse

Entrez Gene: 499073 Rat

Omim: 609235 Human

SwissProt: Q8TDC3 Human

SwissProt: Q5RJI5 Mouse

SwissProt: B2DD29 Rat

Unigene: 182081 Human

Unigene: 297064 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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