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Rabbit Anti-TReP132/AF647 Conjugated antibody (bs-7683R-AF647)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-7683R-AF647
英文名称 Anti-TReP132/AF647
中文名称 AF647标记的乳腺癌抗雌激素抵抗蛋白2抗体
别    名 BCAR2; Breast cancer anti estrogen resistance 2; Breast cancer anti-estrogen resistance 2; RAPA; rapa 1; rapa 2; rapa1; rapa2; RP1 139D8.5; Transcriptional regulating factor 1; Transcriptional regulating protein 132; Transcriptional-regulating factor 1; Transcriptional-regulating protein 132; TREF1_HUMAN; TReP 132; TREP132; TRERF1; Zinc finger protein rapa; Zinc finger transcription factor TReP 132; Zinc finger transcription factor TReP-132.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  染色质和核信号  信号转导  细胞周期蛋白  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 132kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TReP132/RAPA
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. Tissue specificity:Highest expression was seen in thymus, testis and adrenal cortex, expressed also in the adrenal medulla, thyroid, and stomach. Highly expressed in steroidogenic JEG-3 and MCF-7 cells, low expression was seen in non-steroidogenic HepG2 and HK293 cells.

Function:
Activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.

Subunit:
Interacts with CREBBP and EP300.

Subcellular Location:
Nucleus.

Tissue Specificity:
Highest expression was seen in thymus, testis and adrenal cortex, expressed also in the adrenal medulla, thyroid, and stomach. Highly expressed in steroidogenic JEG-3 and MCF-7 cells, low expression was seen in non-steroidogenic Hep-G2 and HEK293 cells.

Similarity:
Contains 3 C2H2-type zinc fingers.
Contains 1 ELM2 domain.
Contains 1 SANT domain.

Database links:

Entrez Gene: 55809 Human

Entrez Gene: 224829 Mouse

Entrez Gene: 316219 Rat

Omim: 610322 Human

SwissProt: Q96PN7 Human

SwissProt: Q8BXJ2 Mouse

Unigene: 485392 Human

Unigene: 260989 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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