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Rabbit Anti-NGFRAP1/PE Conjugated antibody (bs-7671R-PE)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-7671R-PE
英文名称 Anti-NGFRAP1/PE
中文名称 PE标记的神经生长因子受体相关蛋白1抗体
别    名 NADE; BEX3; BEX3_HUMAN; Brain expressed X linked 3 (mouse) homolog; Brain-expressed X-linked protein 3; Nerve growth factor receptor (TNFRSF16) associated protein 1; Nerve growth factor receptor associated protein 1; Nerve growth factor receptor-associated protein 1; NGFRAP1; Ovarian granulosa cell 13.0 kDa protein HGR74; Ovarian granulosa cell protein; p75NTR associated cell death executor; p75NTR-associated cell death executor; Protein BEX3.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  细胞凋亡  细胞膜受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 13kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NADE/NGFRAP1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.
Tissue specificity: Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.

Function:
May be a signaling adapter molecule involved inp75NTR-mediated apoptosis induced by NGF. Plays a role inzinc-triggered neuronal death (By similarity). May play animportant role in the pathogenesis of neurogenetic diseases.

Subunit:
Self-associates. Interacts with 14-3-3 epsilon (YWHAE).Interacts with DIABLO/SMAC (By similarity). Binds to the DEATHdomain of p75NTR/NGFR.

Subcellular Location:
Nucleus. Cytoplasm. Note=Shuttles betweenthe cytoplasm and the nucleus. Associates with replicatingmitochondria (By similarity).

Tissue Specificity:
Found in ovarian granulosa cells, testis,prostate and seminal vesicle tissue. High levels also detected inliver.

Post-translational modifications:
Ubiquitinated. Degraded by the proteasome (By similarity).

Similarity:
Belongs to the BEX family.

Database links:

Entrez Gene: 27018 Human

Entrez Gene: 12070 Mouse

Omim: 300361 Human

SwissProt: Q00994 Human

SwissProt: Q9WTZ9 Mouse

Unigene: 448588 Human

Unigene: 90787 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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