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Rabbit Anti-Leptin/Biotin Conjugated antibody (bs-0409R-Bio)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-0409R-Bio
英文名称1 Rabbit Anti-Leptin/Biotin Conjugated antibody
中文名称 生物素标记的瘦素抗体
别    名 LEP; Leptin Murine Obesity Homolog; Leptin Precursor Obesity Factor; OB; Obese Protein; Obesity; Obesity factor; Obesity homolog mouse; Obesity Murine Homolog Leptin; OBS; LEP_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 免疫学  生长因子和激素  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat,  (predicted: Pig, Sheep, )
产品应用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 16kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Leptin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Leptin, the product of the ob (obese) gene, is a 16kD protein consisting of 146 amino acid residues. Leptin is produced in the adipose tissue, and is considered to play an important role in appetite control, fat metabolism and regulation of body weight. It targets the central nervous system, particularly hypothalamus, affecting food intake. Leptin levels are high in most obese individuals. Studies have shown that it may also influence reproductive function.

Function:
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.

Subunit:
Interacts with SIGLEC6.

Subcellular Location:
Secreted.

DISEASE:
Leptin deficiency (LEPD) [MIM:614962]: A rare disease characterized by low levels of serum leptin, severe hyperphagia and intractable obesity from an early age. Note=The disease is caused by mutations affecting the gene represented in this entry.

Database links:

Entrez Gene: 3952 Human

Entrez Gene: 16846 Mouse

Entrez Gene: 25608 Rat

Omim: 164160 Human

SwissProt: P41159 Human

SwissProt: P41160 Mouse

SwissProt: Q29406 Pig

SwissProt: P50596 Rat

SwissProt: Q28603 Sheep

Unigene: 194236 Human

Unigene: 277072 Mouse

Unigene: 44444 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Leptin是一种分子量为16kDa的脂肪组织源激素,又称:肥胖蛋白(Obese-protein)是由脂肪细胞分泌的,具有强亲水性,以单体形式存在于血浆中。 Leptin 具有广泛的生物学效应,作用于下丘脑,调节食欲、能量代谢及体重。Leptin 还可能作为脂肪-胰岛内分泌轴的一部分,参与胰岛素分泌的调节。
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