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Rabbit Anti-IL-2/Gold Conjugated antibody (bs-1191R-Gold)
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说 明 书: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包装/询价
产品编号 bs-1191R-Gold
英文名称 Anti-IL-2/Gold
中文名称 胶体金标记的白介素2抗体
别    名 Interleukin-2; T-cell growth factor; Aldesleukin; IL 2; Interleukin 2; Interleukin2; Lymphokine; POIL2; T Cell Growth Factor; TCGF; IL2_HUMAN; IL2_MOUSE.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul(10nm  15nm  35nm
研究领域 免疫学  糖蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat, 
产品应用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 15kDa
性    状 Lyophilized or Liquid
浓    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse IL-2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存条件 Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles.
产品介绍 background:
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

Function:
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

Subcellular Location:
Secreted.

DISEASE:
Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

Similarity:
Belongs to the IL-2 family.

Database links:

Entrez Gene: 3558 Human

Entrez Gene: 16183 Mouse

Entrez Gene: 116562 Rat

Omim: 147680 Human

SwissProt: P60568 Human

SwissProt: P04351 Mouse

SwissProt: P17108 Rat

Unigene: 89679 Human

Unigene: 14190 Mouse

Unigene: 9871 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

IL-2作为一种T细胞生长因子在免疫应答及其调节中起重要作用,白介素-2的拮抗剂可用于同种移植排斥、T细胞性白血病以及某些自身免疫性疾病的治疗.胞内IL-2的水平是反映Th1 /Th2型细胞平衡状态的一个有用指标.此抗体只用于大、小鼠。
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