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Rabbit Anti-HO-2/BF647 Conjugated antibody (bs-1238R-BF647)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-1238R-BF647
英文名称1 Rabbit Anti-HO-2/BF647 Conjugated antibody
中文名称 BF647标记的血红素氧合酶2抗体
别    名 Heme oxygenase (decycling) 2; Heme oxygenase (decyclizing) 2; HMOX 2; HMOX2; HMOX2 protein; HO 2; HO2; HMOX2_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  神经生物学  合成与降解  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat,  (predicted: Human, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HO-2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. Summary: catalyzes the conversion of heme to biliverdin; involved in cellular response to oxidative stress [SUBCELLULAR LOCATION] Microsome. Endoplasmic reticulum. [INDUCTION] Heme oxygenase 2 activity is non-inducible. [SIMILARITY] Belongs to the heme oxygenase family.

Function:
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

Subcellular Location:
Microsome. Endoplasmic reticulum.

Similarity:
Belongs to the heme oxygenase family.
Contains 2 HRM (heme regulatory motif) repeats.

Database links:

Entrez Gene: 510243 Cow

Entrez Gene: 479864 Dog

Entrez Gene: 3163 Human

Entrez Gene: 15369 Mouse

Entrez Gene: 100009523 Rabbit

Entrez Gene: 79239 Rat

Omim: 141251 Human

SwissProt: P30519 Human

SwissProt: O70252 Mouse

SwissProt: P43242 Rabbit

SwissProt: P23711 Rat

Unigene: 284279 Human

Unigene: 272866 Mouse

Unigene: 10241 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成与降解(Synthesis and Degradation)
血红素氧合酶是目前发现生物体内最易被诱导产生的抗氧化酶类,其抗氧化作用与它的催化分解产物即胆绿素、胆红素、NO、铁离子和铁蛋白有关。
血红素氧合酶-2基因缺失对血红素诱导的氧化应激性导致的组织损伤具有保护作用;选择性抑制神经元血红素氧合酶-2基因的表达可减轻氧化应激性组织细胞损伤.
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