| 产品编号 | bs-2377R-BF594 |
| 英文名称1 | Rabbit Anti-CNR2/BF594 Conjugated antibody |
| 中文名称 | BF594标记的钙粘蛋白相关的神经受体2抗体 |
| 别 名 | Cannabinoid receptor 2; Cannabinoid Receptor II; Cannabinoid receptor 2 macrophage; CB 2; CB-2; CB2; CNR2; CNRII; CNR-2; CNR 2; CX 5; CX5; CNR2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 神经生物学 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CNR2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 |
background: The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]. Function: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. Subcellular Location: Cell membrane. Cell projection, dendrite. Perikaryon. Localizes to apical dendrite of pyramidal neurons. Tissue Specificity: Preferentially expressed in cells of the immune system with higher expression in B cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root glanglion sensory neurons (at protein level). Post-translational modifications: Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 1269 Human Entrez Gene: 12802 Mouse Omim: 605051 Human SwissProt: P34972 Human SwissProt: P47936 Mouse Unigene: 73037 Human Unigene: 297251 Mouse Unigene: 48776 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 大麻素受体2(大麻素II型受体)CB2受体在正常皮肤主要分布于上皮细胞、巨噬细胞、肥大细胞、感觉神经纤维、毛囊、汗腺等部位, 参与皮肤感觉传导、疼痛机制、皮肤免疫、皮肤肿瘤、细胞分化等重要的生理病理过程. |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
