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Rabbit Anti-Ceramide synthase 2/PE-Cy7 Conjugated antibody (bs-5077R-PE-Cy7)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-5077R-PE-Cy7
英文名称 Rabbit Anti-Ceramide synthase 2/PE-Cy7 Conjugated antibody
中文名称 PE-Cy7标记的肿瘤转移抑制基因1抗体
别    名 LASS2; TMSG-1; CerS 2; CerS2; L3 antibody LAG1 homolog ceramide synthase 2; LAG1 longevity assurance 2; LAG1 longevity assurance homolog 2; LASS 2; Longevity assurance (LAG1 S. cerevisiae) homolog 2; TMSG 1; TMSG1; Tumor metastasis suppressor; Tumor metastasis suppressor gene 1 protein; FLJ10243; MGC987; SP 260; SP260.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  免疫学  信号转导  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LASS2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
LASS2 (LAG1 homolog, ceramide synthase 2) has sequence similarity to yeast longevity assurance gene 1. It is thought to be involved in sphingolipid synthesis. Expression of LASS2 is transiently increased during the period of active myelination and is specifically localized to white matter tracts of the brain, including the Schwann cells of sciatic nerves suggesting that LASS2 is important for the synthesis of dihydroceramide used for synthesis of myelin sphingolipids. Expression of LASS2 in hepatocellular carcinoma cell lines suppresses the growth of cancer cells.

Function:
Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis.

Subcellular Location:
Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in kidney, liver, brain, heart, placenta and lung

Similarity:
Contains 1 homeobox DNA-binding domain.
Contains 1 TLC (TRAM/LAG1/CLN8) domain.

Database links:

Entrez Gene: 29956 Human

Entrez Gene: 76893 Mouse

Omim: 606920 Human

SwissProt: Q96G23 Human

SwissProt: Q924Z4 Mouse

Unigene: 713103 Human

Unigene: 741232 Human

Unigene: 181009 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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