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Rabbit Anti-TBX2/Cy3 Conjugated antibody (bs-0507R-Cy3)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-0507R-Cy3
英文名称 Rabbit Anti-TBX2/Cy3 Conjugated antibody
中文名称 Cy3标记的血栓素B2(一种新发现的抑癌基因)抗体
别    名 T-box2; T-box Protein 2; T-box transcription factor TBX2; T-box protein 2; FLJ10169; HGNC: 11597; T box 2; T box transcription factor TBX2; TBX2_HUMAN; TBX2.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  免疫学  染色质和核信号  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,  (predicted: Human, Rat, Dog, Cow, Rabbit, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 74kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TBX2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.

Function:
Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence.

Subunit:
Interacts with PML (isoform-PML-2, isoform PML-3 and isoform PML-4).

Subcellular Location:
Nucleus (Potential).

Tissue Specificity:
Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.

Similarity:
Contains 1 T-box DNA-binding domain.

Database links:

Entrez Gene: 6909 Human

Entrez Gene: 21385 Mouse

Omim: 600747 Human

SwissProt: Q13207 Human

SwissProt: Q60707 Mouse

Unigene: 531085 Human

Unigene: 287052 Mouse




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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