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Rabbit Anti-Steroid sulfatase/BF647 Conjugated antibody (bs-3857R-BF647)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-3857R-BF647
英文名称 Rabbit Anti-Steroid sulfatase/BF647 Conjugated antibody
中文名称 BF647标记的类固醇硫酸酯酶抗体
别    名 ARSC; ARSC1; Arylsulfatase C; Arylsulfatase C isozyme S; ASC; EC 3.1.6.2; ES; Estrone sulfatase; SSDD; Steroid sulfatase (microsomal); Steroid sulfatase (microsomal) arylsulfatase C isozyme S; Steroid sulfatase; Steryl sulfatase; Steryl sulfatase precursor; Steryl sulfate sulfohydrolase; STS; STS_HUMAN; Steryl-sulfatase; ASC; Steryl-sulfate sulfohydrolase.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  免疫学  染色质和核信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 62kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Steroid sulfatase C-terminus
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to estrogens during pregnancy. The encoded protein is found in the endoplasmic reticulum, where it acts as a homodimer. Mutations in this gene are known to cause X-linked ichthyosis (XLI). [provided by RefSeq, Jul 2008].

Function:
Conversion of sulfated steroid precursors to estrogens during pregnancy.

Subunit:
Homodimer.

Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein.

Post-translational modifications:
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

DISEASE:
Defects in STS are the cause of ichthyosis X-linked (IXL) [MIM:308100]. Ichthyosis X-linked is a keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks.

Similarity:
Belongs to the sulfatase family.

Database links:

Entrez Gene: 412 Human

Omim: 308100 Human

SwissProt: P08842 Human

Unigene: 522578 Human

Unigene: 700558 Human

Unigene: 700559 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

类固醇硫酸酯酶SSDD缺乏,可导致病人的皮肤培养的纤维母细咆、滋养层细胞、外周白细胞、毛球的角化组织、表皮细胞、角质层和甲等变化,见于X连锁鱼鳞病(XLI)。
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