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Rabbit Anti-SUR1/Cy3 Conjugated antibody (bs-3641R-Cy3) ~~~促销,代码KX240301~~~
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-3641R-Cy3
英文名称 Anti-SUR1/Cy3
中文名称 Cy3标记的磺酰脲类药物受体1抗体
别    名 ABC36; Abcc8; ATP binding cassette sub family C (CFTR/MRP) member 8; ATP binding cassette transporter sub family C member 8 (1); HHF1; HRINS; MRP8; PHHI; Sulfonylurea receptor 1; SUR.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 免疫学  细胞膜受体  药物及化合物  糖尿病  内分泌病  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Pig, Horse, Guinea Pig, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 175kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SUR1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
SUR1 is a member of ATP binding cassette super family. SUR receptor confers the sensitivity of Kir6.2 to ATP/ADP sensitivity and to pharmacological agents such as sulfonylurea and diazoxide that close or open the KATP channels. The persistent heyperinsulinimic hypoglycemia in infancy (PHHI) is familial disorder due to defect in negative feed back in response to low glucose levels. SUR1 was mapped on chromosome 11p14-15.1, the same location where the gene for PHHI is located. It has been shown that the expression of Kir6.2 and SUR1 are regulated by glucose levels and the actives of glucogon like peptide receptor 1. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene.

Subunit:
Interacts with KCNJ11.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Similarity:
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains.

Database links:

Entrez Gene: 6833 Human

Entrez Gene: 20927 Mouse

Entrez Gene: 25559 Rat

Omim: 600509 Human

SwissProt: Q09428 Human

SwissProt: Q09429 Rat

Unigene: 54470 Human

Unigene: 11187 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

胰岛β细胞膜含有磺酰脲受体及与之相偶联的ATP敏感的钾通道Ik(ATP),以及电压依赖性的钙通道。当磺酰脲类药物与其受体相结合后,可阻滞Ik(ATP)而阻钾外流,致使细胞膜去极化,增强电压依赖性钙通道开放,胞外钙内流。胞内游离钙浓度增加后,触发胞吐作用及胰岛素的释放。
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