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Rabbit Anti-Phospho-TH (Ser31)/AP Conjugated antibody (bs-3463R-AP)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-3463R-AP
英文名称1 Rabbit Anti-Phospho-TH (Ser31)/AP Conjugated antibody
中文名称 碱性磷酸酶(AP)标记的磷酸化酪氨酸羟化酶抗体
别    名 Tyrosine Hydroxylase (Phospho-Ser31); Dystonia 14; DYT14; DYT5b; EC 1.14.16.2; OTTHUMP00000011225; OTTHUMP00000011226; ple; Protein Pale; TH; The; TY3H_RAT; TYH; Tyrosine 3 hydroxylase; Tyrosine 3 monooxygenase; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 磷酸化抗体 
研究领域 肿瘤  细胞生物  免疫学  神经生物学  信号转导  内分泌病  细胞类型标志物  新陈代谢  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Mouse, Rat, )
产品应用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 56kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from rat TH around the phosphorylation site of Ser31
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Tyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Tyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into Parkinson's disease.

Function:
Plays an important role in the physiology of adrenergic neurons.

Subunit:
Homotetramer.

Subcellular Location:
Mainly expressed in the brain and adrenal glands.

Post-translational modifications:
In vitro, phosphorylation of Ser-19 increases the rate of Ser-40 phosphorylation, which results in enzyme opening and activation.

Similarity:
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Database links:

Entrez Gene: 7054 Human

Entrez Gene: 21823 Mouse

Entrez Gene: 25085 Rat

Omim: 191290 Human

SwissProt: P07101 Human

SwissProt: P24529 Mouse

SwissProt: P04177 Rat

Unigene: 435609 Human

Unigene: 1292 Mouse

Unigene: 11082 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神经细胞标志物
酪氨酸羟化酶(TH)是儿茶酚胺类神经递质即多巴胺、去甲肾上腺素、肾上腺素生物合成过程所需的限速酶,它以四氢生物喋呤啶(BH4)为辅酶,催化酪氨酸的羟化而生成多巴(DOPA)。
已知在患帕金森病(Parkinson disease,PD)时,脑内多巴胺(dopamine,DA)的减少与此酶活性低下有关。因此对PD模型动物来说,若将TH基因植入脑内,便可以提高脑内DA水平而达到基因治疗目的。
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