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Rabbit Anti-Phospho-TCTP(Ser46)/Gold Conjugated antibody (bs-3422R-Gold)
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说 明 书: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包装/询价
产品编号 bs-3422R-Gold
英文名称 Rabbit Anti-Phospho-TCTP(Ser46)/Gold Conjugated antibody
中文名称 胶体金标记的磷酸化翻译控制肿瘤蛋白抗体
别    名 Fortilin; Histamine-releasing factor; p02; p23; TPT1; translationally controlled tumor protein; tumor protein translationally-controlled 1; TCTP_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul(10nm  15nm  35nm
产品类型 磷酸化抗体 
研究领域 肿瘤  细胞生物  免疫学  信号转导  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig, )
产品应用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 20kDa
性    状 Lyophilized or Liquid
浓    度 0.4mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human TCTP around the phosphorylation site of Ser46
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存条件 Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles.
产品介绍 background:
TCTP is involved in calcium binding and microtubule stabilization. It is an immunoglobulin E dependent histamine-releasing factor produced by lymphocytes of atopic children and present in biologic fluids of allergic patients. Both human and mouse recombinant HRF proteins caused histamine release from human basophils of a subpopulation of donors (referenced from OMIM).

Function:
Involved in calcium binding and microtubule stabilization.

Subunit:
Interacts with STEAP3.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate.

Similarity:
Belongs to the TCTP family.

Database links:

Entrez Gene: 7178 Human

Entrez Gene: 22070 Mouse

Entrez Gene: 116646 Rat

Omim: 600763 Human

SwissProt: P13693 Human

SwissProt: P63028 Mouse

SwissProt: P63029 Rat

Unigene: 374596 Human

Unigene: 296922 Mouse

Unigene: 297482 Mouse

Unigene: 36610 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

翻译控制肿瘤蛋白最初发现于肿瘤组织,后来又从其他组织中相继分离出来,是许多动物肿瘤细胞中存在的一类较丰富的蛋白,TCTP参与钙离子结合和微管的稳定,是一类广泛存在于动物、植物及酵母中的、在序列上高度保守且具有很高表达量的蛋白家族。
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