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Rabbit Anti-CRF/APC Conjugated antibody (bs-0246R-APC)
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-0246R-APC
英文名称1 Rabbit Anti-CRF/APC Conjugated antibody
中文名称 APC标记的促肾上腺皮质激素释放因子/促肾上皮质激素释放激素抗体
别    名 Corticoliberin; Corticoliberin precursor; Corticotropin releasing factor; Corticotropin releasing hormone; Corticotropin releasing hormone deficiency included; crf; crh; crh deficiency included; corticoliberin preproprotein; CRF_HUMAN; Corticotropin-releasing factor; CRH1; CRH; Corticotropin-releasing hormone.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 神经生物学  内分泌病  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Rabbit, Guinea Pig, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 5/22kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CRF
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010].

Function:
This hormone from hypothalamus regulates the release of corticotropin from pituitary gland.

Subunit:
Interacts (via C-terminus) with CRFR1 (via N-terminalv extracellular domain).

Subcellular Location:
Secreted.

Similarity:
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Database links:

Entrez Gene: 1392 Human

Entrez Gene: 12918 Mouse

Entrez Gene: 81648 Rat

Omim: 122560 Human

SwissProt: P06850 Human

SwissProt: Q8CIT0 Mouse

SwissProt: P01143 Rat

Unigene: 75294 Human

Unigene: 290689 Mouse

Unigene: 10349 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CRF阳性神经元的胞体广泛分布于下丘脑的室旁核、背缝核和蓝斑核,这些区域也是去甲肾上腺素(NE)神经元与5-羟色胺(5-HT)神经元密集的区域。
CRF既具有神经递质的性质又具有神经激素的性质。CRF是联系神经系统与内分泌系统的桥梁,在情感障碍疾患如焦虑和抑郁的发病中发挥重要作用.
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